Identification of 27-Nor-3.ALPHA.,7.ALPHA.,12.ALPHA.-trihydroxycoprostan-24-one Apparently Derived from 3.ALPHA.,7.ALPHA.,12.ALPHA.-Trihydroxy-24-oxocoprostanoic Acid, a Postulated Intermediate of Bile Acid Biosynthesis.
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چکیده
منابع مشابه
Identification of a novel bile acid in swans, tree ducks, and geese: 3a,7a,15a-trihydroxy-5b-cholan-24-oic acid
By HPLC, a taurine-conjugated bile acid with a retention time different from that of taurocholate was found to be present in the bile of the black-necked swan, Cygnus melanocoryphus. The bile acid was isolated and its structure, established by H and C NMR and mass spectrometry, was that of the taurine N-acyl amidate of 3a,7a,15a-trihydroxy5b-cholan-24-oic acid. The compound was shown to have ch...
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Gallbladder bile of the bullfrog, R a m catesbezana was found to contain a number of minor bile acids and bile alcohols in unconjugated forms. The following bile acids and bile alcohols were identified by combined gas-liquid chromatography-mass spectrometry: cholic acid, allocholic acid, 3a,7a, 12a-trihydroxy-5a-cholestan-26-oic acid, 3a,7a, 12atrihydroxy-24-methyl-5~-cholestan-26-oic acid, 3a,...
متن کاملBile Acids. Xix. Metabolism of Lithocholic Acid-24-14c in the Rat.
Although the principal bile acid formed from cholesterol in the rat is cholic acid (2, 3), Siperstein et al. (4) reported the formation of a small amount of lithocholic acid. Bergstriim, Sjovall, and Voltz (5) reported that lithocholic acid is not converted to cholic acid, but transformed into several unidentified acids. Subsequently, we identified P-muricholic acid (3a, S/3,7/3-trihydroxy-5/3-...
متن کاملRegulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
Under most experimental conditions, the activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase) and cholesterol 7 alpha-hydroxylase, change together in parallel directions. It has been suggested that newly synthesized cholesterol may be the preferred substrate for cholesterol 7 alpha-hydroxylase, which may account for the observed synchronous behavior of the two enzymes. To test...
متن کاملconjugated linoleic acids, amino acid profile and other characteristics of meat produced under identical condition from two iranian fat tailed breeds of lamb
گوشت قرمز یکی از مهم ترین فرآورده های دامی در تأمین پروتئین و انرژی می باشد که در حمل ویتامین های محلول در چربی نیز حائز اهمیت می باشد. انسان مانند سایر مهره داران اسید های چرب ضروری (لینولئیک و آلفا لینولنیک) مورد نیاز خود از طریق غذا تأمین می نماید. اسید های چرب ضروی پیش ساز اسید های چرب غیر اشباع با چند پیوند دوگانه هستند. اسید لینولنیک پیش ساز اسیدهای چرب امگا 3 و اسید لینولئیک نیز پیش ساز ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1993
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.41.1327